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Title   자궁내막증식증 및 자궁내막암에서 Bcl-2 종양 유전자의 발현에 관한 연구 ( Bcl-2 Expression in Endometrial Hyperplasia and Carcinoma )
Publicationinfo   1998 Jan; 030(06): 1207-1219.
Key_word   Endometrial hyperplasia, Endometrial carcinoma, Bcl-2 oncogene
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Abstract   Purpose: To speculate the role of bcl-2 protooncogene in endometrial carcinogenesis by determination of the expression of bcl-2 in endometrial hyperplasia and carcinoma. Materials and Methods: We studied bcl-2 expression by an immunohistochemical method in the paraffin-embedded blocks of 78 patients with endometrial hyperplasia, 64 with simple hyperpasia, 9 with complex hyperplasia and 5 with atypical hyperplasia respectively, and 33 endometrial carcinoma treated at Asan Medical Center from June, 1989 to May, 1997. Intensity of bcl-2 staining was scored on a scale of 0 to 4, calibrated by comparison with stromal lymphocytes, which always received a score of 4. Results: The results of this study showed that bcl-2 was relatively highly expressed in simple (n= 64), complex (n=9) and atypical hyperplasias (n=5) with mean staining scores of 2.95+-1.09 (Mean+Standard Deviation), 2.78+-1.20 and 3.60+-0.89 respectively, which showed no difference among histologic types. In endometrial carcinoma, the expression of bcl-2 was significantly down regulated (mean score=1.76+- 1.35) compared with that of hyperplasia, and did not conelate with FIGO surgical stage. However, grade III tumor showed significantly lower expression that grade I or II tumor. Conclusion: Bcl-2 expression is down regulated in endometrial carcinoma than endo- metrial hyperplasia, and correlates with tumor grade, which suggest that bcl-2 expression might be the result of carcinogenesis or bcl-2 plays only an adjunctive role in the endometrial carcinogenesis.
저 자   김종혁(Jong Hyeok Kim),고창원(Chang Won Koh),허주령(Joor Yung Huh),김봉희(Bong Hee Kim),공훈식(Hun Sik Kong),나준희(Jun Hee Na),김용만(Yong Nam Kim),김영탁(Young Tak Kim),남주현(Joo Hyun Nam),목정은(Joo Hyun Nam)